The Specificity of Antibodies Elicited by Poly(dG)-Poly(dC) |
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| Authors: | Eileen M Lafer B David Stollar |
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| Institution: | Tufts University School of Medicine, Department of Biochemistry and Pharmacology , 136 Harrison Ave., Boston , Mass , 02111 |
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| Abstract: | Abstract Antibodies have been raised to the synthetic DNA polymer poly(dG)·poly(dC). These antibodies have the ability to distinguish this right-handed polymer from natural mixed sequence DNA, as well as from other right- and left-handed synthetic DNA polymers. They show reduced but measurable binding to synthetic polymers which contain various combinations of guanine and cytosine polynucleotides suggesting that both helical shape and sequence are recognized by this antiserum. |
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| Keywords: | mushroom tyrosinase ligand-based pharmacophore virtual screening molecular dynamic simulations inhibitor LigandScout |
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