152 Order from disorder: defining structure in disordered proteins |
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| Authors: | Shana Elbaum-Garfinkle Garrett Cobb Abhinav Nath |
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| Affiliation: | 1. Department of Molecular Biophysics &2. Biochemistry , Yale University , 266 Whitney Avenue, Bass 234, New Haven , CT , 06511 , USA Phone: Tel: 203-432-5342 Fax: Tel: 203-432-5342 |
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| Abstract: | Intrinsically disordered proteins are involved in a range of functional roles in the cell, as well as being associated with a number of diverse diseases, including cancers, neurodegenerative disorders, and cardiac myopathies. We use single-molecule fluorescence approaches to characterize disordered proteins implicated in the progression of Parkinson’s and Alzheimer’s diseases. Our goal is to understand, how disease-associated modifications to these proteins alter their conformational and dynamic properties and to relate these changes to disease pathology. | |
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