L-Asparaginase: A Promising Chemotherapeutic Agent |
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| Authors: | Neelam Verma Kuldeep Kumar Gurnoor Kaur Sneh Anand |
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| Institution: | 1. Biosensor Technology Lab, Department of Biotechnology, Punjabi University, Patiala, Punjab, India;2. Department of Biotechnology, Punjabi University, Patiala, Punjab, India;3. Department of Biomedical Engineering, Indian Institute of Technology, Delhi, India |
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| Abstract: | ABSTRACTThis article comprises detailed information about L-asparaginase, encompassing topics such as microbial and plant sources of L-asparaginase, treatment with L-asparaginase, mechanism of action of L-asparaginase, production, purification, properties, expression and characteristics of l-asparaginase along with information about studies on the structure of L-asparaginase. Although L-asparaginase has been reviewed by , our effort has been to include recent and updated information about the enzyme covering new aspects such as structural modification and immobilization of L-asparaginase, recombinant L-asparaginase, resistance to L-asparaginase, methods of assay of L-asparagine and L-asparaginase activity using the biosensor approach, L-asparaginase activity in soil and the factors affecting it. Also, side-effects of L-asparaginase treatment in acute lymphoblastic leukemia (ALL) have been discussed in the current review. L-asparaginase has been and is still one of the most widely studied therapeutic enzymes by researchers and scientists worldwide. |
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| Keywords: | L-asparaginase Acute Lymphoblastic Leukemia (ALL) recombinant biosensor immobilization therapeutic |
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