Role of the Environment in the Interaction of Nonintercalators with Z-DNA |
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| Authors: | K. Ekambareswara Rao N. Ramesh D. Choudhury S. K. Brahmachari V. Sasisekharan |
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| Affiliation: | Molecular Biophysics Unit , Indian Institute of Science , Bangalore , 560012 , India |
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| Abstract: | Abstract Interaction of the DNA binding nonintercalators Netropsin, Distamycin and the mPD derivative with Z-DNA has been studied. It has been found that environmental factors like the solvent and added cations significantly modulate the interaction of these ligands with ZDNA However no definite Z to B transition in presence of these ligands was found in any case, in contrast to previously reported results (Ch.Zimmer, C.Marek and W.Guschlbauer, FEBS Lett. 154, 156–160(1983)). |
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