Prediction of 3-D Structure of the Cro Protein from Phage 434 |
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| Authors: | Miroslaw Cygler Wayne F Anderson |
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| Institution: | 1. Department of Crystallography , University of Lodz , 91-416, Lodz , Nowotki 18, Poland;2. MRC Group on Protein Structure and Function, Department of Biochemistry , University of Alberta , Edmonton , Alberta , T6G 2H7 , Canada |
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| Abstract: | Abstract A comparative model building process has been utilized to predict (he three-dimensional structure of the bacteriophage 434 Cro protein, Amino acid sequence similarities between the 434 Cro protein and other bacteriophage repressor and Cro proteins have been used, in conjunction with secondary structure prediction and the known structures of other base sequence specific DNA binding proteins, to derive the model. From this model the interactions between the 434 Cro protein and its operator DNA have been deduced. These proposed interactions are consistent with the known properties of the bacteriophage 434 Cro protein. |
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