Hypericin Site Specific Interactions Within Polynucleotides Used as DNA Model Compounds |
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| Authors: | Pavol Miskovsky Laurent Chinsky Gavin V Wheeler Pierre-Yves Turpin |
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| Institution: | 1. Biophysics Division , Safarik University , Jesenna 5, 041 54 , Kosice , Slovakia;2. L.P.B.C. (CNRS URA 2056), Institut Curie &3. Université Pierre et Marie Curie , 11 rue Pierre et Marie Curie, 75231 , Paris Cedex 05 , France |
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| Abstract: | Summary Interactions of the antiretroviral hypericin molecule with polynucleotides, i.e. poly(dG-dC), poly(dA-dT), poly(rG) and poly(rC), have been studied in aqueous solutions by resonance Raman spectroscopy, using an UV excitation wavelength which induces a specific resonance enhancement of spectral band intensities corresponding to proper nucleic base modes of vibration. It is shown that : i) hypericin selectively interacts with the N7 sites of purines, ii) the strength of interaction depends on the polymer structure, and : iii) interaction with guanine is stronger than with adenine molecules. |
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