Interaction Specificity of Benzimidazol Group Compounds with AT-Containing Polynucleotides |
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| Authors: | Nina M. Akimenko Alexander V. Garabadgiu Igor Ya Skuratovskii Janos Sagi Anna Szabolcs Katalin Ebinger |
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| Affiliation: | 1. Engelhardt Institute of Molecular Biology Russian Academy of Sciences , Moscow , 117984 , Russia;2. Institute of Technology , Saint-Petersburg , 198013 , Russia;3. Institute of Molecular Genetics Russian Academy of Sciences , Moscow , 123182 , Russia;4. Central Research Institute for Chemistry Hungarian Academy of Sciences , H-1525 , Budapest , Hungary |
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| Abstract: | Abstract The interaction between polynucleotides: poly(dA)-poly(dT), poly(dA-dT), poly(am2dA- dT), and the AT-specific compounds of benzimidazol group has been studied. It is been shown that these compounds bind to poly(dA)-poly(dT) and poly(dA-dT) at low and high salt concentration in solution. Poly(am2dA-dT) interacts with AT-specific compounds only at low salt, where this polynucleotide is in a B-form, but not at high salt when the polynucleotide converts to another conformation. Thus, the interaction specificity of the groove-binding ligands is influenced not only by the minor groove substituents, but the peculiarities of the secondary structure of polynucleotides. |
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