Glucose and lactate utilization by the amygdala of male and female rats |
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Authors: | Rasia-Filho Alberto A Fin Cyntia A Alves Marcelle Possa Marianne A Roehrig Cintia Feoli Ana Maria Silva Luciane Perry Marcos L S |
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Affiliation: | (1) Departmento de Ciências Fisiológicas, Fundação Faculdade Federal de Ciências Médicas, R. Sarmento Leite 245, Porto Alegre, RS, 90050-170, Brazil;(2) Departmento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, R. Ramiro Barcelos 2600, anexo, Porto Alegre, RS, 90035-003, Brazil |
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Abstract: | Gonadal hormones appear to modulate brain energy metabolism, and morphological and functional sexual differences are found in the amygdaloid complex (AC) of rats. Our aim was to study the CO2 production and lipid synthesis, measured by the rate of L-[U-14C]lactate or D-[U-14C]glucose utilization (in pmol.hr–1.mg–1), by AC slices in vitro of male and female rats. Lactate was more used than glucose as energy substrate (p < 0.01) but no sex-related difference was observed in glucose or lactate oxidation to CO2 (p > 0.05) or on lipid synthesis obtained from both substrates (p > 0.05). In addition, there was no effect of the estrous cycle on lactate oxidation to CO2 by the AC of females (p > 0.05). Based on the present data, it appears that the endogenous normal levels of gonadal hormones are not able to promote sex-related differences in the in vitro glucose or lactate utilization by the AC of rats. |
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Keywords: | Amygdaloid complex brain metabolism oxygen consumption |
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