Induction of respiration-deficient mutants in Saccharomyces cerevisiae by chelerythrine |
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| Authors: | Viktor Krivjanský Margita Obernauerová Jitka Ulrichová Vilém &#;imánek Július &#;ubík |
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| Institution: | Department of Microbiology and Virology, Faculty of Sciences, Comenius University, Mlynskádolina B-2, 842 15 Bratislava, Slovak Republic; Institute of Medical Chemistry, Medical Faculty, PalackýUniversity, 775 15 Olomouc, Czech Republic |
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| Abstract: | Abstract Chelerythrine and sanguinarine, two structurally related benzo/c/phenanthridine alkaloids, prevented growth of yeast cells in medium containing either glucose or non-fermentable carbon sources. At concentrations permitting growth of the yeast Saccharomyces cerevisiae , chelerythrine, but not sanquinarine, induced cytoplasmic respiration-deficient mutants. The petite clones that were analysed exhibited suppressiveness and contained different fragments of the wild-type mitochondrial genome. |
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| Keywords: | Alkaloid Chelerythrine Sanguinarine Saccharomyces cerevisiae Petite mutant Yeast |
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