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Aryl sulfones: a new class of gamma-secretase inhibitors |
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| Authors: | Teall Martin Oakley Paul Harrison Timothy Shaw Duncan Kay Euan Elliott Jason Gerhard Ute Castro José L Shearman Mark Ball Richard G Tsou Nancy N |
| Affiliation: | Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK. martin_teall@merck.com |
| Abstract: | The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived gamma-secretase inhibitors for the potential treatment of Alzheimer's disease is described. |
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