Burkholderia cepacia complex infection in a cohort of Italian patients with cystic fibrosis |
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Authors: | Lambiase Antonietta Raia Valeria Stefani Stefania Sepe Angela Ferri Pasqualina Buonpensiero Paolo Rossano Fabio Del Pezzo Mariassunta |
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Institution: | Department of Biology and Pathology, Luigi Califano, University of Naples Federico II, Italy. alambias@unina.it |
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Abstract: | The aims of this study were to detect Burkholderia cepacia complex (Bcc) strains in a cohort of Cystic Fibrosis patients (n=276) and to characterize Bcc isolates by molecular techniques. The results showed that 11.23% of patients were infected by Bcc. Burkholderia cenocepacia lineage III-A was the most prevalent species (64.3%) and, of these, 10% was cblA positive and 50% esmR positive. Less than half of the strains were sensitive to ceftazidime, meropenem, piperacillin tazobactam, and trimethoprim-sulfamethoxazole. About half of the strains (41%) had homogeneous profiles, suggesting cross-transmission. The infection by B. cenocepacia was associated to a high rate of mortality (p=0.01). |
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