Sequence of Two mRNAs Encoding Active Rat Tryptophan Hydroxylase |
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| Authors: | Michè le C. Darmon,Bernard Guibert,Vincent Leviel,Mireille Ehret,Michel Maitre,Jacques Mallet |
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| Affiliation: | Laboratoire de Neurobiologie Cellulaire, CNRS, Gif-sur-Yvette; France. |
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| Abstract: | Two full-length cDNA clones that encode functional rat tryptophan hydroxylase (EC 1.14.16.4), the key enzyme in serotonin synthesis, have been isolated from a rat pineal gland library. These two clones correspond to the 1.8- and 4-kilobase mRNA species, respectively. They contain the same coding sequence corresponding to a 51,010-dalton protein and differ in the length of their 3' untranslated regions. |
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| Keywords: | Tryptophan hydroxylase Aromatic amino acid hydroxylases Pineal gland Molecular cloning |
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