The influence of the trichorzianin C-terminal residues on the ion channel conductance in lipid bilayers |
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Authors: | H Duclohier G Molle G Spach |
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Affiliation: | Polymères, Biopolymères Membranes' URA 500 CNRS, Faculté des Sciences de Rouen, Mont Saint Aignan, France. |
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Abstract: | Four natural trichorzianin analogues, channel-forming peptaibols, differing in their C-terminal residues (Gln or Glu, Trpol or Pheol) were tested for their macroscopic and single-channel conductances in planar lipid bilayers. The results indicate that, as regards to the voltage threshold, the most efficient analogue is the charged Trpol-bearing one. In addition, Trpol brings about a drastic lengthening of the open channel life-times. This behaviour is attributed to the dipole moment of the end residues and to the bulkiness and hydrogen bonding ability of Trpol. |
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