Cutting edge: tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-alpha-induced suppression of B lymphocyte formation |
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| Authors: | Shimoda Kazuya Kamesaki Kenjirou Numata Akihiko Aoki Kenichi Matsuda Tadashi Oritani Kenji Tamiya Sadafumi Kato Kouji Takase Ken Imamura Rie Yamamoto Tetsuya Miyamoto Toshihiro Nagafuji Koji Gondo Hisashi Nagafuchi Seiho Nakayama Kei-Ichi Harada Mine |
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| Affiliation: | First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan. kshimoda@intmed1.med.kyushu-u.ac.jp |
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| Abstract: | IFN-alpha inhibits B lymphocyte development, and the nuclear protein Daxx has been reported to be essential for this biological activity. We show in this study that IFN-alpha inhibits the clonal proliferation of B lymphocyte progenitors in response to IL-7 in wild-type, but not in tyk2-deficient, mice. In addition, the IFN-alpha-induced up-regulation and nuclear translocation of Daxx are completely abrogated in the absence of tyk2. Therefore, tyk2 is directly involved in IFN-alpha signaling for the induction and translocation of Daxx, which may result in B lymphocyte growth arrest and/or apoptosis. |
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