Carbon catabolite regulation of rebeccamycin production inSaccharothrix aerocolonigenes |
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| Authors: | Kin Sing Lam Jacqueline Mattei Salvatore Forenza |
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| Affiliation: | (1) Pharmaceutical Research and Development Division, Bristol-Myers Company, P.O. Box 5100, 06492 Wallingford, CT, U.S.A. |
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| Abstract: | Summary A new antitumor antibiotic named rebeccamycin was isolated from fermentations of an actinomycete,Saccharothrix aerocolonigenes. A defined medium was developed to study the regulation of synthesis of rebeccamycin byS. aerocolonigenes. In glucose medium formation of rebeccamycin was detected only after glucose was depleted. Examination of eleven different carbon sources revealed that carbon catabolite regulation is a major control mechanism for rebeccamycin production. |
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| Keywords: | Rebeccamycin Saccharothrix aerocolonigenes Carbon catabolite regulation Antitumor antibiotic |
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