| 二元调控系统PhoP-PhoQ在细菌中的调控作用 |
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| 引用本文： | 秦珑,杨瑞馥. 二元调控系统PhoP-PhoQ在细菌中的调控作用[J]. 生物技术通讯, 2006, 17(3): 402-404 |
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| 作者姓名： | 秦珑 杨瑞馥 |
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| 作者单位： | 军事医学科学院,微生物流行病研究所,北京,100071 |
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| 摘 要： | PhoP-PhoQ是一种二元调控系统,它调控着细菌的毒力,参与细菌对Mg2 限制性生长环境的适应,而且还调节几种革兰阴性细菌的许多细胞活性。本文对PhoP-PhoQ感知Mg2 浓度的变化、与靶基因的启动子区结合引起靶基因的上调和下调,尤其是对脂质A的结构修饰和细菌毒力的调控作用作一介绍。
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| 关 键 词： | PhoP-PhoQ二元调控系统 转录调控 Mg2 脂质A 毒力 |
| 文章编号： | 1009-0002（2006）03-0402-03 |
| 收稿时间： | 2006-01-31 |
| 修稿时间： | 2006-01-31 |
The Regulation of a Two-Component System PhoP-PhoQ in Bacteria |
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| QIN Long,YANG Rui-fu. The Regulation of a Two-Component System PhoP-PhoQ in Bacteria[J]. Letters in Biotechnology, 2006, 17(3): 402-404 |
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| Authors: | QIN Long YANG Rui-fu |
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| Abstract: | The PhoP-PhoQ two-component system can govern virulence,help bacteria to adapt to Mg2 -limiting environments,and regulate numerous cellular activities in several Gram-negative bacteria.In this review,the mechanisms of sensing Mg2 ,the binding promotor regions of target genes,up-regulation or down-regulation of genes,the modification of lipid A and regulation of virulence by PhoP-PhoQ were summarized. |
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