Stimulus-dependent changes in calcium metabolism in rabbit neutrophils |
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| Authors: | T F Molski P H Naccache R I Sha'afi |
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| Institution: | 1. Department of Physiology, University of Connecticut Health Center Farmington, CT 06032 U.S.A.;7. Department of Pathology, University of Connecticut Health Center Farmington, CT 06032 U.S.A. |
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| Abstract: | We have found that the changes in calcium metabolism in rabbit neutrophils produced by the chemotactic synthetic peptide f-Met-Leu-Phe are not sensitive to the calcium chelator EGTA. The present results demonstrate unambiguously that the previously described chemotactic factor induced changes in 45Ca fluxes in rabbit neutrophils do indeed reflect intracellular events. The pool of calcium mobilized by f-Met-Leu-Phe and increase in cell associated 45Ca upon stimulation are both insensitive to the presence of EGTA. |
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| Keywords: | reprint requests to TFPM |
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