Simple method for determination of terbutaline plasma concentration by high-performance liquid chromatography |
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Authors: | Vanessa L. Herring Julie A. Johnson |
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Abstract: | A method is described in which low nanomolar concentrations of terbutaline in plasma can be quantitated by use of a standard isocratic high-performance liquid chromatography system with electrochemical detection. Samples were prepared for injection by solid-phase extraction and preserved from degradation by addition of glutathione. Terbutaline and internal standard metaproterenol were resolved from plasma constituents on a single C18 column by ion-pairing chromatography. The method is precise and accurate for measurement of freebase concentrations as low as 4.4 nmol/l (1 ng/ml). |
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Keywords: | Terbutaline |
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