Nervous system and primary liver cancer |
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| Authors: | Seogsong Jeong Bo Zheng Hongyang Wang Qiang Xia Lei Chen |
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| Institution: | 1. Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, PR China;2. International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, PR China;3. National Center for Liver Cancer, Shanghai 201805, PR China |
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| Abstract: | Recent advances have found irregular activities of the nervous system-associated factors in the development and progression of primary liver cancer. These factors contributed in the regulation of migration, proliferation, and apoptosis of cancer cells, and took a role in modulating invasion, metastasis, and recurrence after curative treatment. In clinical researches, neural-related factors were found to be significant prognostic factors, suggesting that the interactions between nervous system and primary liver cancer are indispensable in understanding underlying biological mechanisms. Herein, we reviewed up-to-date achievements in this area and the future perspectives of the interactions between the nervous system and primary liver cancer. |
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| Keywords: | Nervous system Neural regulation Neurotransmitters Hepatocellular carcinoma Intrahepatic cholangiocarcinoma Prognostic factors |
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