Mitochondrial ion channels |
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Authors: | Skalska Jolanta Debska-Vielhaber Grazyna G?ab Marta Kulawiak Bogusz Malińska Dominika Koszela-Piotrowska Izabela Bednarczyk Piotr Do?owy Krzysztof Szewczyk Adam |
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Institution: | Pracownia Wewnatrzkomórkowych Kana?ów Jonowych, Instytut Biologii Do?wiadczalnej PAN im. Marcelego Nenckiego, Warszawa. |
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Abstract: | Ion channels are proteins, which facilitate the ions flow throught biological membranes. In recent years the structure as well as the function of the plasma membrane ion channels have been well investigated. The knowledge of intracellular ion channels however is still poor. Up till now, the calcium channel described in endoplasmatic reticulum and mitochondrial porine are the examples of intracellular ion channels, which have been well characterized. The mitochondrial potassium channels: regulated by ATP (mitoK(ATP)) and of big conductance activated by Ca2+ (mitoBK(Ca)), which were described in inner mitochondrial membrane, play a key role in the protection of heart muscle against ischemia. In this review the last date concerning the mitochondrial ion channels as well as they function in cell metabolism have been presented. |
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