The Tombusvirus-encoded P19: from irrelevance to elegance |
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Authors: | Scholthof Herman B |
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Affiliation: | Department of Plant Pathology and Microbiology and Intercollegiate Faculty of Virology, Texas A&M University, 2132 TAMU, College Station, Texas 77843, USA. herscho@tamu.edu |
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Abstract: | Since its discovery in the late 1980s, the status of the Tombusvirus-encoded p19 protein (P19) changed from being thought obsolete to its identification a decade later as an important viral pathogenicity factor. The recent finding that P19 suppresses RNA interference (RNAi) by appropriating short interfering RNAs led to its widespread use as an RNAi-probing tool in various plant and animal models. Here, I discuss how our knowledge of p19 has developed over the years, with emphasis on the relevance of understanding its biological roles during Tombusvirus infection of plants. |
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