A suggested chain process for radiation damage

It has been suggested that when an organism is exposed to ionizing radiation the initial damage results from the occurrence of ionization in a so-called sensitive volume due to absorption of radiation quanta. The initial radiation damage is then transmitted or amplified to a level of macroscopic perception. In this paper a mechanism by which this transmission may take place and a finite Markov chain model applicable to this transmission are postulated and discussed. This mechanism is assumed to be the depolymerization of essential chain molecules which are connected to some “central group” associated with the seensitive volume. The depolymerization of the macromolecules following a hit in the sensitive volume is postulated to be determined by a chain mechanism, which acts in a manner inverse to the mechanism controlling the polymerization process. A mathematical study of this problem is made using the theory of Markov chains. The probability of complete degradation of the chain macromolecule, and the probability of recombination of the units to give the intact chain were determined, assuming that the probabilty of successive steps in the degradation increase linearly from the intact state to that of complete breakdown.