The nuclear localization of a putative neurotransmitter receptor |
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| Authors: | S C Bondy K R Cameron A K Agrawal |
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| Institution: | (1) Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, P.O. Box 12233, 27709 Research Triangle Park, North Carolina;(2) Present address: Industrial Toxicology Research Center, P.O. Box 80, 226001 Lucknow, India |
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| Abstract: | A high affinity strychnine binding site has been identified within a membrane fraction prepared from partially purified rat brain nuclei. This interaction appears similar in its characteristics to that occurring in the non-nuclear membrane fraction which is thought to occur at the synaptic glycine receptor complex. Both the nuclear and non-nuclear membrane binding of tritiated strychnine is greater within the pons-medulla region than in the cerebral cortex. Nuclear membrane binding sites for dopamine, norepinephrine ( -adrenergic), acetylcholine (muscarinic), GABA, and diazepam were not detected. |
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