Synthesis of some oligodeoxynucleotides containing the C-nucleoside and 2'-deoxy-2'-fluoronucleoside moieties. |
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| Authors: | I Rosenberg Z Tocik K A Watanabe |
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| Affiliation: | Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division of Graduate School of Medical Sciences, Cornell University, New York, NY 10021. |
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| Abstract: | An automated computer-controlled, multipurpose synthesizer, featuring a novel method for the transport of liquids, was constructed and used in the synthesis of oligomers containing some C-nucleoside and 2'-deoxy-2'-fluoronucleoside moieties by the H-phosphonate procedure. The synthetic method and some prospects for biological use are outlined. |
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