Past,present, and emerging roles of mitochondrial heat shock protein TRAP1 in the metabolism and regulation of cancer stem cells |
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Authors: | Chang-Nim Im |
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Affiliation: | 1.Department of Biochemistry, College of Medicine,The Catholic University of Korea,Seoul,Korea;2.Institute for Aging and Metabolic Diseases, College of Medicine,The Catholic University of Korea,Seoul,Korea;3.Cancer Evolution Research Center, College of Medicine,The Catholic University of Korea,Seoul,Korea |
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Abstract: | Tumor necrosis factor receptor-associated protein 1 (TRAP1), a member of the HSP90 family, controls a variety of physiological functions, including cell proliferation, differentiation, and survival. Most studies have been devoted to understanding the anti-apoptotic roles of TRAP1 in cancer and targeting it for tumor control in clinical settings. Additionally, we have identified a new role for TRAP1 in regulation of liver regeneration after partial hepatectomy in TRAP1 transgenic mice and cellular proliferation in TRAP1-overexpressing cells, via mitochondrial alterations. Moreover, recent works have indicated a role for TRAP1 in the regulation of cancer stem cells (CSCs) as well as a metabolic switch between mitochondrial respiration and aerobic glycolysis called as “Warburg effect.” This review discusses the implications of TRAP1 action for both metabolism and the regulation of CSCs. |
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