The activity of antimicrobial peptide S-thanatin is independent on multidrug-resistant spectrum of bacteria |
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Authors: | Wu Guoqiu Li Xiaofang Fan Xiaobo Wu Hongbin Wang Shenglan Shen Zilong Xi Tao |
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Affiliation: | a Center of Clinical Laboratory Medicine of Zhongda Hospital, Southeast University, Nanjing 210009, China b Biotechnology Center, Department of Life Science and Biotechnology, China Pharmaceutical University, Tongjiaxian 24#, Nanjing 210009, China |
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Abstract: | In this study, the activity of S-thanatin (an analog of antimicrobial peptide derived from thanatin) against different bacterial pathogens frequently which can cause therapeutic problems was tested. The result showed minimal inhibitory concentrations (MICs) of S-thanatin against all isolates of the Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter aerogenes, Klebsiella ornithinolytica and Klebsiella oxytoca were in the range of 4-16 μg/ml, no matter which antibiotic the bacterial was resistant or susceptible, while almost all MICs to Gram-positive bacterial were >128 μg/ml except Enterococcus faecium. S-thanatin was more effective toward Gram-negative strains, especially for Enterobacter and Klebsiella. The MICs of S-thanatin were no significantly different in the same species regardless of antibiotic sensitive or -resistant isolates to single or multiple antibiotic (P > 0.05). Likewise, no notable difference could be observed between E. coli, K. pneumoniae, E. cloacae, E. aerogenes, K. ornithinolytica which were sensitive to S-thanatin (P > 0.05). It was implied that the antimicrobial activity of S-thanatin was independent on multi-drug resistance spectrum of bacteria. |
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Keywords: | Antimicrobial peptide Thanatin Antimicrobial activity Clinical isolate |
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