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Hyperleptinemia in obese adolescents deregulates neuropeptides during weight loss
Authors:Dâmaso Ana R  de Piano Aline  Sanches Priscila L  Corgosinho Flávia  Tock Lian  Oyama Lila M  Tock Luciana  do Nascimento Claudia M Oller  Tufik Sérgio  de Mello Marco Túlio
Institution:a Biosciences Department, Federal University of São Paulo - Paulista Medicine School - UNIFESP-EPM, São Paulo, Brazil
b Post Graduate Program of Interdisiciplinary Health Sciences, Federal University of São Paulo - Paulista Medicine School - UNIFESP-EPM, São Paulo, Brazil
c Post Graduate Program of Nutrition, Federal University of São Paulo - Paulista Medicine School - UNIFESP-EPM, São Paulo, Brazil
d Physiology Department, Federal University of São Paulo - Paulista Medicine School - UNIFESP-EPM, São Paulo, Brazil
e Endocrinology Department, Federal University of São Paulo - Paulista Medicine School - UNIFESP-EPM, São Paulo, Brazil
f Psychobiology Department, Federal University of São Paulo - Paulista Medicine School - UNIFESP-EPM, São Paulo, Brazil
Abstract:Leptin has emerged over the past decade as a key hormone not only in energy balance regulation but also in neuroendocrine and inflammatory processes. The aim of the present study was to evaluate whether hyperleptinemia deregulates neuropeptides during weight loss. A total of 86 post-pubertal obese adolescents (with or without hyperleptinemia) participated in one year of interdisciplinary weight loss therapy (clinical, nutritional, psychological and exercise-related). Adipokine and neuropeptide concentrations were measured by ELISA, visceral fat was measured by ultrasound and body composition was measured by pletismography. The hyperleptinemic patients presented a lower alpha-MSH concentration and higher NPY/AgRP ratio while the adiponectin/leptin (A/L) ratio was lower compared with the non-hyperleptinemic group. After therapy, significant improvements in BM, BMI, body fat mass, visceral and subcutaneous fat, HOMA-IR, QUICKI, total cholesterol and triglycerides were observed in both groups. Indeed, we observed significant increases in adiponectin and A/L as well as reductions in leptin and NPY/AgRP ratio in the hyperleptinemic group. In the stepwise multiple linear regression analysis with leptin concentration as the dependent variable, α-MSH and body fat mass (%) were the independent predictors to explain leptin concentration. For the entire group, we found positive correlations between leptinemia and BMI and body fat mass (%) as well as a negative correlation with free fat mass (%) and alpha-MSH. Finally, we verified negative correlations between adiponectin/leptin ratio with total cholesterol and LDL-c, only in hyperleptinemic patients. In conclusion, the hyperleptinemia in obese adolescents deregulates neuropeptides during weight loss.
Keywords:Leptin  Obesity  Neuropeptides  Adolescent
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