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Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin |
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| Authors: | Lee Seokjoon Oh Sangtae Park Gab-Man Kim Tong-Soo Ryu Jae-Sook Choi Han-Kyu |
| Institution: | Department of Basic Science, Yonsei University, Womju, Korea. sjlee@kd.ac.kr |
| Abstract: | Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10 beta-benzenesulfonyl-dihydroartemisinin showed stronger antimalarial activity than artemisinin. |
| Keywords: | Plasmodium falciparum antimalarial activity artemisinin dihydroartemisinin synthesis natural product |
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