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ANTIPROLIFERATIVE EFFECT OF ILLIMAQUINONE ON LEISHMANIA MEXICANA |
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| Authors: | HECTOR R RANGEL FRACEHULI DAGGER REINALDO S COMPAGNONE |
| Institution: | 1. University Department of Chemical Technology, Dr Babasaheb Ambedkar Marathwada University, Aurangabad, 431004, Maharashtra, India;2. Vilasrao Deshmukh Foundation, Group of Institutions, VDF School of Pharmacy, Latur, 413 531, Maharashtra, India;1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;2. Research Institute for Fundamental Sciences (RIFS), University of Tabriz, Tabriz, Iran;3. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran;4. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;5. Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran |
| Abstract: | Illimaquinone, a sponge metabolite that disrupts the Golgi complex in mammalian cells, stopped proliferation and induced morphological and ultrastructural changes in promastigotes of L. mexicana Radioactive labeling of proteins demonstrates an increased excretion function and diminution of membrane acid phosphatase activity, due probably to the vesiculation of the Golgi complex and alteration of the cell protein sorting mechanism. The result indicated that illimaquinone could be useful for the study of intracellular traffic in Trypanosomatidae. |
| Keywords: | illimaquinone protein sorting Leishmania Golgi complex acid phosphatase |
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