Human laminin a chain (LAMA) gene: Chromosomal mapping to locus 18p11.3 |
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Authors: | Toshiro Nagayoshi, Marie-Genevi ve Mattei, Edith Passage, Robert Knowlton, Mon-Li Chu,Jouni Uitto |
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Affiliation: | Department of Dermatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania. |
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Abstract: | Laminin, an integral component of basement membranes, consists of three subunit polypeptides, A, B1, and B2 chains. We have recently isolated cDNAs corresponding to human laminin A chain. These cDNAs were utilized for chromosomal in situ hybridizations to establish the genomic location of the laminin A chain gene. Metaphase chromosomes of PHA-stimulated human peripheral blood leukocytes were examined by in situ hybridization with 3H-labeled cDNAs, and the chromosomes were identified by R-banding (fluorochrome-photolysis-Giemsa method). The results indicated that the human laminin A chain is at locus 18p11.3. Since human laminin B1 and B2 chain genes have been previously mapped to chromosomes 7 and 1, respectively, the results indicate that genes encoding human laminin chains reside in separate chromosomes. |
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