| NO调控下丘脑钙激活钾通道的机制研究 |
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| 引用本文： | Wang S,Wang ZG,Zhang XD,Zou F. NO调控下丘脑钙激活钾通道的机制研究[J]. 中国应用生理学杂志, 2002, 18(1): 5-8 |
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| 作者姓名： | Wang S Wang ZG Zhang XD Zou F |
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| 作者单位： | 1. 白求恩国际和平医院神经外科,河北,石家庄,050082
2. 第一军医大学高温医学研究室,广东,广州,510515 |
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| 基金项目： | 自然科学基金海外合作项目 ( 3992 90 0 1) |
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| 摘 要： | 目的 :研究NO对下丘脑神经元钙激活钾通道 (KCa)的作用及其机制。方法 :采用膜片钳技术内面向外式及细胞贴附式。结果 :NO可直接或通过升高cGMP来提高KCa通道的开放概率 (Po) ,这种增强作用是因为通道开放时间延长及开放频率增加。结论 :下丘脑神经元中NO可通过不同机制激活KCa。
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| 关 键 词： | NO 下丘脑神经元 钙激活钾通道 膜片钳技术 |
| 文章编号： | 1000-6834(2002)01-0005-04 |
| 修稿时间： | 2000-10-23 |
Research of regulation on calcium-activated potassium channel in hypothalamic neurons by nitric oxide |
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| Wang Shuai,Wang Zhen-Gang,Zhang Xu-Dong,Zou Fei. Research of regulation on calcium-activated potassium channel in hypothalamic neurons by nitric oxide[J]. Chinese journal of applied physiology, 2002, 18(1): 5-8 |
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| Authors: | Wang Shuai Wang Zhen-Gang Zhang Xu-Dong Zou Fei |
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| Affiliation: | WANG Shuai 1,WANG Zhen-gang 1,ZHANG Xu-dong 1,ZOU Fei 2 |
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| Abstract: | Aim:To study the effects of nitric oxide on calcium-activated potassium channels (KCa) in hypothalamus neurons.Methods: The data was recorded by adopting cell-attached or inside-out configuration of patch-clamp technique. Results:Nitric oxide was found to increase the open probability of the channels directly or through increasing cGMP,which resulted from both the prolongation of open period and increase of open frequency. Conclusion: Nitric oxide could regulate calcium-activated potassium channels in hypothalamic neurons through alternative pathways. |
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| Keywords: | nitric oxide hypothalamus calcium-activated potassium channels patch-clamp technique |
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