Calcium ion activation of the anion-conducting channel in the rat liver mitochondrial inner membrane. |
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| Authors: | M J Selwyn C L Ng H L Choo |
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| Affiliation: | Department of Biochemistry, Faculty of Medicine, National University of Singapore. |
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| Abstract: | Stimulation of the rat liver mitochondrial inner-membrane anion-conducting channel by aeration is dependent on the concentration of Ca2+ ions in the assay medium. Ca2+ activates anion conduction in both aerated and non-energised mitochondria but acts over a wider concentration range and produces a greater increase in anion-conductivity in aerated mitochondria. EGTA reverses Ca2+ stimulation but takes several seconds to act, indicating slow release of Ca2+ from the activation site possibly on the matrix side of the inner mitochondrial membrane. It is suggested that this channel may respond to hormone-induced changes in cytosolic Ca2+ concentration. |
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