The tRNA‐like small noncoding RNA mascRNA promotes global protein translation |
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| Authors: | Xinping Lu Jinliang Huang Sipeng Wu Qian Zheng Peipei Liu Huimin Feng Xiaoqing Su Haipeng Fu Qiaoran Xi Geng Wang |
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| Institution: | 1. MOE Key laboratory of Bioinformatics, Cell Biology and Development Center, School of Life Sciences, Tsinghua University, Beijing China ; 2. State Key laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Fujian China |
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| Abstract: | mascRNA is a small cytoplasmic RNA derived from the lncRNA MALAT1. After being processed by the tRNA processing enzymes RNase P and RNase Z, mascRNA undergoes CCA addition like tRNAs and folds into a tRNA‐like cloverleaf structure. While MALAT1 functions in multiple cellular processes, the role of mascRNA was largely unknown. Here, we show that mascRNA binds directly to the multi‐tRNA synthetase complex (MSC) component glutaminyl‐tRNA synthetase (QARS). mascRNA promotes global protein translation and cell proliferation by positively regulating QARS protein levels. Our results uncover a role of mascRNA that is independent of MALAT1, but could be part of the molecular mechanism of MALAT1''s function in cancer, and provide a paradigm for understanding tRNA‐like structures in mammalian cells. |
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| Keywords: | MALAT1 mascRNA multi‐ tRNA synthetase complex translation tRNA‐ like structure |
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