Chaperoned protein disaggregation--the ClpB ring uses its central channel |
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Authors: | Horwich Arthur L |
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Institution: | Howard Hughes Medical Institute and Department of Genetics, Yale University School of Medicine, New Haven, CT 06536 USA. |
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Abstract: | In this issue of Cell, exploit a clever manipulation of the Hsp100 ring chaperone, ClpB, to gain some mechanistic and physiologic understanding of the action of this chaperone in mediating ATP-dependent disaggregation of protein aggregates that accumulate in the bacterial cytoplasm under severe heat shock conditions. |
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