植物油对大鼠应激性胃粘膜损伤的保护作用

将大鼠捆缚后置于4℃冰箱3h,造成应激性胃粘膜损伤,损伤程度用损伤指数表示:(1)在应激前3h 用0.5、1.0、2.Oml 的花生油灌胃,使损伤指数从对照的18.8—22.6降为6.8—7.0,P<0.01,但当花生油用量降至0.25ml 时,其保护作用不明显;(2)在应激前0.5、1.5、2.5和3.5h用1.0ml 花生油灌胃,也均有保护作用,(3)菜籽油或油酸有类似花生油的抗胃粘膜损伤作用,而且油酸的作用比花生油更显著,但30%甘油却无效;(4)将1.0ml 花生油注入空肠,具有与灌胃相似的保护作用;(5)在大鼠应激前1.5h 肌注消炎痛(10mg/kg),并不能阻断花生油的保护作用。以上结果表明,花生油等植物油能够通过其脂肪酸成分作用于小肠而产生对抗应激性胃粘膜损伤的作用。这种保护作用的机理不明,但似与前列腺素无关。

CYTOPROTECTIVE EFFECT OF VEGETABLE OIL ON STRESS-INDUCED GASTRIC MUCOSAL DAMAGE IN RATS

The effect of vegetable oil on gastric mucosal damage induced by cold-restraintstress in rats was studied.The results were as follows:(1)Peanut oil administered orally in doses of 0.5,1.0 and 2.0 ml,3 hours beforestress may significantly inhibit the development of gastric mucosal damage,butlower dose(0.25ml)was without effect.(2)The cytoprotective effect of peanutoil administered orally 0.5,1.5,2.5 and 3.5 hours before stress was also obvious.(3)Rapseed oil and oleic acid also exerted a significantly cytoprotective effect similarto that of peanut oil,but 30% glycerin did not.(4)The action of peanut oil intro-duced into jejunum was the same as that administered orally.(5)Indomethacincould not abolish the cytoprotection of peanut oil.From the above results it is suggested that vegetable oil may exert a significantcytoprotective effect on stress-induced gastric mucosal damage.This effect mightbe produced by the fatty acid component of the oil acting at proximal part of thesmall intestine.The mechanism of this effect remains to be shown,but it doesnot seem to be mediated by prostaglandins.