TIP: protein backtranslation aided by genetic algorithms |
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Authors: | Moreira Andrés Maass Alejandro |
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Institution: | Centro de Modelamiento Matemático and Departamento de Ingeniería Matemática FCFM, U. de Chile, Casilla 170/3-Correo 3, Santiago, Chile. anmoreir@dim.uchile.cl |
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Abstract: | Several applications require the backtranslation of a protein sequence into a nucleic acid sequence. The degeneracy of the genetic code makes this process ambiguous; moreover, not every translation is equally viable. The usual answer is to mimic the codon usage of the target species; however, this does not capture all the relevant features of the 'genomic styles' from different taxa. The program TIP ' Traducción Inversa de Proteínas') applies genetic algorithms to improve the backtranslation, by minimizing the difference of some coding statistics with respect to their average value in the target. AVAILABILITY: http://www.cmm.uchile.cl/genoma/tip/ |
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