Optimal process/solvent design for ethanol extractive fermentation with cell recycling |
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| Institution: | 1. Department of Biosystems and Agricultural Engineering, Oklahoma State University, Stillwater, OK 74078, USA;2. Department of Natural Resource Ecology and Management, Oklahoma State University, Stillwater, OK 74078, USA;1. URD Agro-Biotechnologies Industrielles (ABI), CEBB, AgroParisTech, 51110 Pomacle, France;2. Abolis Biotechnologies, Genopole Campus 1, 5 rue Henri Desbruères, 91030 Evry, France;3. Université Paris-Saclay, INRAE, AgroParisTech, UMR SayFood (Paris-Saclay Food and Bioproduct Engineering Research Unit), 78850 Thiverval Grignon, France;1. URD Agro-Biotechnologies Industrielles (ABI), CEBB, AgroParisTech, Pomacle 51110, France;2. Abolis Biotechnologies, Genopole Campus 1, Evry 91030, France;1. Department of Technology, Savitribai Phule Pune University, Ganeshkhind, Pune 411007, India;2. Praj Matrix – R&D Center, Division of Praj Industries Ltd, Urawade, Pirangut, Pune 412115, India;1. Graduate Program of Chemical Engineering, Federal University of São Carlos, C.P. 676, São Carlos, SP, 13565-905, Brazil;2. Federal Institute of Education, Science and Technology of São Paulo, Campus Capivari, Capivari, SP, 13360-000, Brazil |
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| Abstract: | In this study, the computer-aided process/solvent design is introduced to find an optimal biocompatible solvent and to maximize the ethanol production rate simultaneously for the single- or double-stage extractive fermentation process with cell recycling. Such a process/solvent design problem is formulated as a mixed-integer nonlinear programming problem that is solved by mixed-integer hybrid differential evolution in order to obtain a global design. The double-stage process can use a smaller amount of fresh solvent to increase ethanol productivity compared with that of the single-stage process, but it will also decrease overall conversion. Comparing the case studies, the simultaneous process/solvent design could yield higher overall ethanol productivity than that of the process design. The maximum ethanol production rate for the double-stage extractive fermentation with cell recycling was about 10-fold higher than that of continuous fermentation and about twofold higher than that of continuous fermentation with cell recycling. |
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