Moving RNA moves RNA forward |
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Authors: | LiNa Peng YuJiao Li Lan Zhang WenQiang Yu |
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Institution: | 1. Key Laboratory of Ministry of Education, Department of Molecular Biology, Fudan University, Shanghai, 200032, China 2. EpiRNA Laboratory, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China 3. School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China
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Abstract: | Cell communication affects all aspects of cell structure and behavior, such as cell proliferation, differentiation, division, and coordination of various physiological functions. The moving RNA in plants and mammalian cells indicates that nucleic acid could be one of the various types of messengers for cell communication. The microvesicle is a critical pathway that mediates RNA moving and keeps moving RNA stable in body fluids. When moving miRNA enters the target cell, it functions by altering the gene expression profile and significantly inhibiting mRNA translation in recipient cells. Thus, moving RNA may act as a long-range modulator during development, organogenesis, and tumor metastasis. |
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