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Large-scale study of long non-coding RNA functions based on structure and expression features |
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| Authors: | Yi Zhao Jian Wang XiaoWei Chen HaiTao Luo YunJie Zhao Yi Xiao RenSheng Chen |
| Affiliation: | 2. Bioinformatics Research Group, Advanced Computing Research Laboratory, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, 100190, China 3. Department of Physics, Huazhong University of Science and Technology, Wuhan, 430074, China 1. Laboratory of Bioinformatics and Non-coding RNA, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China |
| Abstract: | Mammals and other complex organisms can transcribe an abundance of long non-coding RNAs (lncRNAs) that fulfill a wide variety of regulatory roles in many biological processes. These roles, including as scaffolds and as guides for protein-coding genes, mainly depend on the structure and expression level of lncRNAs. In this review, we focus on the current methods for analyzing lncRNA structure and expression, which is basic but necessary information for in-depth, large-scale analysis of lncRNA functions. |
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