Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers |
| |
Authors: | Accardo Antonella Tesauro Diego Mangiapia Gaetano Pedone Carlo Morelli Giancarlo |
| |
Institution: | Department of Biological Sciences, CIRPeB University of Naples Federico II, & IBB CNR, Via Mezzocannone 16, 80134 Naples, Italy. |
| |
Abstract: | The self-assembling behavior, at physiological pH, of the amphiphile peptide (C18)(2)L5CCK8 in nanostructures is reported. Stable aggregates presenting a critical micellar concentration of 2 x 10(-6) mol kg(-1), and characterized by water exposed CCK8 peptide in beta-sheet conformation, are obtained. Small angle neutron scattering experiments are indicative for a 3D structure with dimensions > or =100 nm. AFM images confirm the presence of nanostructures. Fluorescence experiments indicating the sequestration of pyrene, chosen as drug model, and the anticancer Doxorubicin within the nanostructures are reported. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|