Reversal of BoNT/A-mediated inhibition of muscle paralysis by 3,4-diaminopyridine and roscovitine in mouse phrenic nerve-hemidiaphragm preparations |
| |
| Authors: | Michael Adler Sharad S. Deshpande James P. Apland Bridget Murray Andrew Borrell |
| |
| Affiliation: | 1. Neurobehavioral Toxicology Branch, Analytical Toxicology Division, U.S. Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, APG, MD 21010-5400, USA;2. Department of Chemistry and Biochemistry, University of Massachusetts, 285 Old Westport Road, Dartmouth, MA 02747-2300, USA |
| |
| Abstract: | Botulinum neurotoxins (BoNTs) comprise a family of neurotoxic proteins synthesized by anaerobic bacteria of the genus Clostridium. Each neurotoxin consists of two polypeptide chains: a 100 kDa heavy chain, responsible for binding and internalization into the nerve terminal of cholinergic motoneurons and a 50 kDa light chain that mediates cleavage of specific synaptic proteins in the host nerve terminal. Exposure to BoNT leads to cessation of voltage- and Ca2+-dependent acetylcholine (ACh) release, resulting in flaccid paralysis which may be protracted and potentially fatal. |
| |
| Keywords: | Botulinum neurotoxin 3,4-Diaminopyridine Roscovitine Acetylcholine Mouse Diaphragm muscle Aminopyridine Potassium channel blocker Calcium channel agonist Bioterrorism |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
