CCL28 in the mouse hippocampal CA1 area and the dentate gyrus during and after pilocarpine-induced status epilepticus |
| |
Authors: | Jian Xin Liu Xia Cao Yong Liu Feng Ru Tang |
| |
Affiliation: | 1. Institute of Neurobiology, Xi’an Jiaotong University College of Medicine, Xi’an 710061, PR China;2. Department of Neurosurgery, the 2nd Affiliated Hospital of Kunming Medical University, Kunming 650101, PR China;3. Temasek Laboratories, National University of Singapore, Singapore |
| |
Abstract: | The present study showed a wide presence of CCL28 in mouse CNS, including cerebral, cerebellum, brain stem and spinal cord. In hippocampus, the expression of CCL28 at both mRNA and protein level was clarified. The CCL28 expression was mainly localized in pyramidal cells of CA area, granular cells of dentate gyrus and some interneurons in CA area and hilus. Double-labelling immunocytochemistry revealed that most of calbindin, calretinin and parvalbumin immunopositive neurons expressed CCL28. During and after pilocarpine induced status epilepticus (SE), a down-regulated expression of CCL28 in hippocampal interneurons in the CA1 area and in the hilus of the dentate gyrus was demonstrated. The present study may, therefore provide evidence that CCL28 may have a novel role in CNS and may be involved in the loss of hippocampal interneurons, and subsequent disinhibition of pyramidal neurons. |
| |
Keywords: | Chemokine CCL28 Hippocampus Status epilepticus |
本文献已被 ScienceDirect 等数据库收录! |
|