| Abstract: | The effects of denervation upon the Meissner corpuscle were evaluated by sequential fingertip biopsies in 3 rhesus monkeys, following transection of all the sensory innervation of the hand. Histological techniques were used to identify changes in the neural, connective, and enzymatic components of the Meissner corpuscles. Denervation of the Meissner corpuscle resulted in rapid and complete degeneration of the axon terminal and a slowly progressive degeneration of the connective tissue component of the corpuscle, characterized by loss of lobulation, lamellar collapse, and a steadily diminishing corpuscular size. The physiological basis and the clinical implications of these findings are discussed. The literature is reviewed. |
