Microbiological transformation of two labdane diterpenes, the main constituents of Madia species, by two fungi |
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| Authors: | Haridy Mamdouh S A Ahmed Ahmed A Doe Matsumi |
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| Institution: | Department of Botany, Faculty of Science, El-Minia University, El-Minia 61519, Egypt. |
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| Abstract: | Microbial transformation of 13R,14R,15-trihydroxylabd-7-ene (5) and 13R,14R,15-trihydroxylabd-8(17)-ene (6) by the fungus Debaryomyces hansenii gave 1 (13R,14R,15-trihydroxy-6-oxolabd-8-ene) and 3 (7alpha,13R,14R,15-tetrahydroxy-labd-8(17)-ene), respectively. While, microbial transformation of 5 by Aspergillus niger afforded 2 (3beta,13R,14R,15-tetrahydroxy-labd-7-ene), and 13R,14R,15-trihydroxylabd-8,17-ene (6) gave 3 and 4 (3R,14R,15-3-oxotetrahydroxy-labd-7-ene). The structures of the new compounds, 1 and 2, were assigned by 1D and 2D high-field NMR spectroscopic methods. Antimicrobial activity of these compounds were tested and their MIC were determined. |
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| Keywords: | Labdane diterpenes Oxidation Madia species Asteraceae Microbial transformation Debaryomyces hansenii Aspergillus niger NMR |
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