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Influence of obstetric factors on osteogenic potential of umbilical cord-derived mesenchymal stem cells |
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| Authors: | Letizia Penolazzi Renata Vecchiatini Stefania Bignardi Elisabetta Lambertini Elena Torreggiani Alessandro Canella Tiziana Franceschetti Giorgio Calura Fortunato Vesce Roberta Piva |
| Affiliation: | (1) Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, Ferrara, Italy;(2) Department of Medico-Surgical Disciplines of Communication and Behaviour, University of Ferrara, Ferrara, Italy;(3) Department of Biomedical Sciences and Advanced Therapies, Section of Obstetric and Gynaecological Clinic, Azienda Ospedaliero-Universitaria S Anna, Ferrara, Italy;(4) Department of Reconstructive Science, University of Connecticut Health Center, Farmington, Connecticut, USA |
| Abstract: | Wharton's jelly from the umbilical cord is a noncontroversial source of mesenchymal stem cells (WJMSCs) with high plasticity, proliferation rate and ability to differentiate towards multiple lineages. WJMSCs from different donors have been characterized for their osteogenic potential. Although there is large evidence of WJMSCs plasticity, recently scientific debate has focused on MSCs selection, establishing predictable elements to discriminate the cells with most promising osteoprogenitor cell potential. |
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