The crystal structure of Haloferax volcanii proliferating cell nuclear antigen reveals unique surface charge characteristics due to halophilic adaptation |
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| Authors: | Jody A Winter Panayiotis Christofi Shaun Morroll and Karen A Bunting |
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| Institution: | (1) Institute of Genetics, University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, UK;(2) Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK |
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| Abstract: | Background The high intracellular salt concentration required to maintain a halophilic lifestyle poses challenges to haloarchaeal proteins
that must stay soluble, stable and functional in this extreme environment. Proliferating cell nuclear antigen (PCNA) is a
fundamental protein involved in maintaining genome integrity, with roles in both DNA replication and repair. To investigate
the halophilic adaptation of such a key protein we have crystallised and solved the structure of Haloferax volcanii PCNA (HvPCNA) to a resolution of 2.0 ?. |
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