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Control of replication initiation by the Sum1/Rfm1/Hst1 histone deacetylase
Authors:Jan M Weber  Horst Irlbacher  Ann E Ehrenhofer-Murray
Institution:1.Zentrum für Medizinische Biotechnologie, Universit?t Duisburg-Essen,Essen,Germany;2.Bayer Schering Pharma,Berlin,Germany
Abstract:

Background  

Replication initiation at origins of replication in the yeast genome takes place on chromatin as a template, raising the question how histone modifications, for instance histone acetylation, influence origin firing. Initiation requires binding of the replication initiator, the Origin Recognition Complex (ORC), to a consensus sequence within origins. In addition, other proteins bind to recognition sites in the vicinity of ORC and support initiation. In previous work, we identified Sum1 as an origin-binding protein that contributes to efficient replication initiation. Sum1 is part of the Sum1/Rfm1/Hst1 complex that represses meiotic genes during vegetative growth via histone deacetylation by the histone deacetylase (HDAC) Hst1.
Keywords:
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