Platelet adhesion onto the wall of a flow chamber with an obstacle |
| |
Affiliation: | 1. Institute of Aeronautics and Astronautics, College of Medicine,National Cheng Kung University, Tainan, Taiwan, Republic of CHINA;2. Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of CHINA;1. Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass;2. Wyss Institute of Biologically Inspired Engineering of Harvard University, Boston, Mass;3. Division of Health Sciences Technology, Harvard-MIT, Cambridge, Mass;1. Department of Chemistry, Bangalore University, Central College Campus, Palace Road, Bangalore 560001, India;2. Department of Studies in Molecular Biology, University of Mysore, Manasagangotri, Mysore 570006, India;3. Tsinghua Berkeley Shenzhen Institute, Tsinghua University, Shenzhen, Guangdong, PR China;4. Adichunchanagiri Institute for Molecular Medicine, BG Nagara-571448, Nagamangala Taluk, Mandya District, India;5. Department of Studies in Physics, University of Mysore, Manasagangotri, Mysore 570006, India;6. Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, United Kingdom;7. Department of Studies and Research in Biochemistry, Tumkur University, Tumkur 572101, India;8. Institution of Excellence, Vijnana Bhavan, University of Mysore, Manasagangotri, Mysore 570006, India;9. Department of Studies in Organic Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India;1. CEMAT, IST, Universidade de Lisboa, Portugal;2. Dipartimento di Matematica, “U. Dini”, Università degli studi di Firenze, Italy;3. FIAB SpA, Firenze, Italy;4. Istituto di Analisi dei Sistemi ed Informatica (IASI) Antonio Ruberti, CNR, Italy;5. Departamento de Matemática and CEMAPRE, ISEG, Universidade de Lisboa, Portugal;6. Departamento de Matemática and CEMAT, IST, Universidade de Lisboa, Portugal;1. MOE Key Laboratory of Laser Life Science, South China Normal University, Guangzhou 510006, China;2. Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China;1. Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan;2. Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan;3. Department of Pathology, Keio University School of Medicine, Tokyo, Japan |
| |
Abstract: | In the present study, the data of the initial adhesion of platelets onto the wall of a flow chamber with an obstacle in steady human blood flows were obtained. The flowfields and the distribution of stress-related factors were simulated numerically by a finite volume method and the fluid dynamic effect on the platelet adhesion is discussed. In addition to the wall shear effect, the normal stress effect was also taken into account. A parameter Vn/¦Vt¦ was devised to assess the combined effect of both shear and normal forces in platelet adhesion. It was found that the peak adhesion occurred next to, but not on, the impingement point on the obstacle where the value of Vn/¦Vt¦ was negative. In these regions, direct impact played a major role in platelet adhesion. On the other hand, near the separation point before the obstacle where Vn/¦Vt¦ was insignificant, the mechanism was believed to be different from that in the direct impact region. Denser adhesion there might be caused by the accumulation and frequent collision of particles due to flow retardation and/or detour of the flow path. Interestingly, relatively low adhesion was found inside the recirculation regions. These results show that the normal stress effect (impingement) should be considered in platelet adhesion in addition to the shear effect. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|