Ultrastructural elements of CNS development in the Stage 15 Drosophila (Diptera: Drosophilidae) embryo |
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| Affiliation: | 1. Neuroscience Training Program Department of Entomology University of Wisconsin, Madison, WI 53706, U.S.A.;2. Department of Entomology University of Wisconsin, Madison, WI 53706, U.S.A.;1. Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 W. Baltimore Avenue, Baltimore, MD 21201, USA;1. School of Arts, Sciences and Humanities of the University of São Paulo, Av. Arlindo Bettio, 1000 – Ermelino Matarazzo, 03828-000 São Paulo, São Paulo, Brazil;2. School of Arts, Sciences and Humanities of the University of Sao Paulo, Rua Francisco Manoel da Silva,17, 09171040 Santo André, São Paulo, Brazil;3. School of Arts, Sciences and Humanities of the University of Sao Paulo, Rua Cayowaá, 1366 – ap. 94, 05018-001 São Paulo, São Paulo, Brazil;1. Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand;2. Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand;3. Te Kupenga Hauora Māori, University of Auckland, Auckland, New Zealand;4. Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand;5. Discipline of Oncology, University of Auckland, Auckland, New Zealand;6. He Kamaka Waiora, Waitemata and Auckland District Health Boards, Auckland, New Zealand;7. Auckland, New Zealand;8. Te Pua Wānanga Faculty of Māori and Indigenous Studies, University of Waikato, Hamilton, New Zealand;9. He Oranga Hauora Healthier Lives National Science Challenge, University of Otago, Dunedin, New Zealand;1. Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan;2. Department of Zoology and Neurobiology, University of Kaiserslautern, 67663 Kaiserslautern, Germany;1. Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada |
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| Abstract: | The ultrastructural neuroanatomy of the wild-type Drosophila melanogaster (Diptera: Drosophilidae) embryo at Stage 15 was examined with the transmission electron microscope. This particular embryonic stage is an approximate midpoint of neurogenesis. No blood-brain barrier has yet formed in the CNS as illustrated by lanthanum tracer infiltration into the neuropil. First structural signs of axo-axonal synapses, in the embryonic neuropil are seen as electron-dense plaques on the cytoplasmic sides of apposing pre- and postsynaptic membranes. Very few clear synaptic vesicles (30–40 nm in diameter) are present, and none of these is clustering, although some are docking on the presynaptic membrane. In the perikaryal rind of the ventral ganglion, several glial somata are shown surrounding a single neuronal soma. Finger-like processes of the glial somata extend into extracellular spaces and contact the surface of the neuron. The functional significance of these findings is discussed. |
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