Carbopol-Based Gels for Nasal Delivery of Progesterone |
| |
Authors: | Grace Rathnam N Narayanan R Ilavarasan |
| |
Institution: | (1) Department of Pharmaceutics, C.L. Baid Metha College of Pharmacy, Thorapakkam, Chennai, 600097, India;(2) Department of Pharmaceutics, Madras Medical College, Chennai, 600001, India;(3) Captain Srinivas Murthi Drug Research, Institute for Ayurveda and Siddha, Arumbakkam, Chennai, 600106, India |
| |
Abstract: | The purpose of this study was to investigate the nasal absorption of progesterone from carbopol-based nasal gels in rabbits.
Progesterone nasal gels were prepared by dispersing carbopol 974 (1%, 1.5%, and 2%) in distilled water followed by addition
of progesterone/progesterone–β cyclodextrin complex dissolved in propylene glycol then neutralization. The potential use of
β cyclodextrin (CD) as nasal absorption enhancer by simple addition, as a physical mixture and as a complex with progesterone
was investigated. The absolute bioavailability of progesterone from nasal gels in rabbits was studied by estimating the serum
progesterone level by competitive solid-phase enzyme immunoassay in comparison to intravenous injection. The carbopol gel
formulations produced a significant increase in bioavailability. CD complex promotes the nasal absorption of progesterone
from carbopol gels as compared with gels where the CD is added by simple addition and gels which do not contain CD. This method
of addition of CD as an inclusion complex in the gels could be considered as a preferred platform in nasal drug administration. |
| |
Keywords: | cyclodextrins gels nasal delivery progesterone |
本文献已被 PubMed SpringerLink 等数据库收录! |
|